Zeitschrift für klinische Toxikologie
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Clinical and CT Manifestations of Delayed Toxic Encephalopathy caused by Low-Dose Chlorfenapyr Poisoning: A Case Report

Changjian Qiu*, Huan Sun, Hongqi Xiao, Yuan Cao

Case: A 13-year-old girl attemped to suicide by ingesting only 10 ml of 10% chlorfenapyr. She presented with toxic encephalopathy after a latent period of more than a week, and rapidly progressed to death within days of symptoms. Chlorfenapyr intoxication could result in severe diaphoresis, high fever, general fatigue, rhabdomyolysis, and
neurologic symptoms. Brain Computed Tomography (CT) showed a diffused impairment of white matter, brain stem, and cerebellum as well as wide edema in grey matter regions. Discussion: The chlorfenapyr mainly impairs the function of energy-consuming vital organs and lead to corresponding clinical symptoms, and we should be treated it with caution at the first visit. Chlorfenapyr intoxication exhibited a latent period from 7 to 14 days, even asymptomatic patients should be actively observed. Commercial chlorfenapyr is lipophilic, and early multiple hemoperfusion is necessary.