Zeitschrift für Frauengesundheit
Offener Zugang

Abstrakt

Efficacy and Tolerability of an Innovative Detergent on Feminine Hygiene (Saugella Hydraserum) In a Controlled Clinical Study in an Italian Population

Martini E, Terreno E, Nappi R, Cianci A, De Leo V

Abstract

Background/Aims: In daily feminine hygiene in women prone to genital dryness, it is rational to use a specific detergent (SH) containing less aggressive natural surfactants which stimulate epidermal renewal of keratinocytes, agents increasing bioadhesiveness of hydrating components; and plant extracts with natural antimicrobial, and antiinflammatory activity. This study evaluated efficacy and acceptability of SH (Saugella Hydraserum) compared with a standard detergent (C) in women with vaginal dryness.

Methods: Women of childbearing potential with vaginal dryness were randomised to treatment with SH or with C, b.i.d. for 4 weeks in a controlled, balanced, parallel-group study stratified by clinical condition. Clinical evaluations were performed at baseline and every week.

Results: A total of 120 women were treated, 60 per treatment, mean age 32.6 years, with dryness due to hormone deficiency or hypersensitive to normal detergents.

Symptoms severity was significantly reduced in favour of SH for pruritus (67.4% ± 7.4 vs -36.8% ± 7.5, p<0.01), burning (-65.3% ± 7.4 vs -36.9% ± 7.2, p<0.05), erythema (-80.3% ± 6.6 vs -39.2% ± 9.8, p<0.05), dryness (-52.9% ± 7.1vs -16.2% ± 5.0, p<0.001), dyspareunia (-44.9% ± 6.2 vs -16.7% ± 6.6, p<0.05).

Conclusions: Saugella Hydraserum showed better clinical efficacy than normal intimate detergent on pruritus, burning, erythema, dryness, and dyspareunia in women with vulvovaginal dryness. This outcome was obtained by the combination of natural surfactants, offering skin protection, and a complex of active substances, aimed both at normal hydration of the external genitalia and prevention of microbial contamination.