Globales Journal für Biowissenschaften und biologische Forschung
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Humangenetik 2016: Durch Schwangerschaftskomplikationen hervorgerufene epigenetische Veränderungen können die spätere Entwicklung von Herz-Kreislauf- und zerebrovaskulären Erkrankungen bei der Mutter auslösen – Ilona Hromadnikova – Karls-Universität, Tschechische Republik

Ilona Hromadnikova, Katerina Kotlabova, Lucie Hympanova and Ladislav Krofta

Aim: To demonstrate that pregnancy complications are associated with alterations in cardiovascular and cerebrovascular microRNA expression in maternal circulation. We focused on microRNAs playing a role in pathogenesis of dyslipidemia, hypertension, vascular inflammation, insulin resistance and diabetes, atherosclerosis, angiogenesis, coronary artery disease, myocardial infarction and heart failure. Methods: Gene expression of 29 microRNAs was compared between groups (39 GH, 68 PE, 33 IUGR and 20 normal pregnancies) and correlated with the severity of the disease with respect to clinical signs, delivery date and Doppler US parameters.