Zeitschrift für Alkoholismus und Drogenabhängigkeit
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Abstrakt

Synthesis of amino alcohols short communication

Dr Evgeny M. Krupitsky

amino Alcohols are the versatile intermediates within the preparation of the many biologically active compounds also as in pharmaceutical industry. The synthesis of those structures is achieved by various routes but the only way is ring opening of epoxide by an amine. There are several difficulties in making these molecules viz reaction conditions, role of catalyst, stereo effects etc. This review focuses on ring opening of epoxides under different conditions to realize amino alcohols. One important class of cyclic amino alcohols is that the poly hydroxylated alkaloids, also referred to as aza-sugars, e.g. castanospermine that was found to be a potent inhibitor of ?- and ?-glucosidases. Peptidomimetics constitutes an outsized group of synthetically produced pharmacologically active amino alcohols, most ordinarily Renin and HIV-1 protease inhibitors, for instance Saquinavir.