Zeitschrift für Krebswissenschaft und -forschung
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Targeted Magnetic Nanoparticle Hyperthermia for the Treatment of Oral Cancer

Santosh BS, Harish Kumar A, Tulima Begum*, Supriya Bhandage, Jerin Jose

Oral squamous cell carcinoma is a common cancer worldwide. Apart from surgery, chemotherapy and radiotherapy have been tried in the treatment of oral cancers. However these treatment modalities have their own side effects in the course of treatment. Recently, several methods such as targeted therapy alone or in combination with chemotherapy have been employed for the treatment of oral cancer. Hyperthermia in the recent times with the use of mangnetic nanoparticles (MNP) have been shown as a promising therapy in reducing the disease. This article applies a review of literature to understand the basic features of hyperthermic cell death, the mechanism of action of magnetic nanoparticles hyperthermia, application of MNPs in the diagnosis and treatment of oral cancer, the potential hazards, and the future prospectives.