Zeitschrift für klinische und experimentelle Dermatologieforschung
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A Comparative Study of Glycolic Acid Versus Mixture of Trichloroacetic Acid and Glycolic Acid Peeling for Treatment of Three Benign Epidermal Lesions

Mohamed H Khater, Khaled Gharib, Eman H Abdelbary and Manal R Abd El-haleem

Background: Chemical peeling is one of the dermatological treatments available for improvement of appearance of skin.

Objectives: To evaluate the clinical effects of focal Glycolic acid 70% (GA) peel versus focal mix of Trichloroacetic acid 50% (TCA) and GA 70% peel in epidermal lesions including seborrheic keratosis, actinic keratosis and solar lentigines.

Methods: An analysis was done on 60 adult patients with the previous epidermal lesions. They were divided into two groups, group1 treated by focal GA 70% peel and group 2 treated by focal mix peeling. The peel was repeated every 2 weeks for 6 sessions.

Results: In group 1, 50% of seborrheic keratosis showed fair improvement (5/30) and 50% poor improvement (5/30). In actinic keratosis, there were 20% excellent (2/30), 50% good (5/30) and 30% fair improvement (3/30). In solar lentigines, there was 50% fair improvement (5/30) and 50% poor improvement (5/30). While, with group 2 there was 50% excellent (5/30), 40% good (4/30) and 10% fair (1/30) cure of seborrheic keratosis lesions. There was 30% excellent (3/30), 50% good (5/30) and 20% fair (2/30) cure of actinic keratosis lesions. There was 50% fair improvement (5/30) in number and color of solar lentigines and 50% poor improvement (5/30).

Conclusion: The focal mix peel method is an effective safer modality for treatment of some epidermal lesions than focal GA peeling.