Chemotherapie: Offener Zugang
Offener Zugang

Abstrakt

A Potential Multigene Biomarker for Predicting Benefit of Chemotherapy Gastric Cancer

Pin Wang

This is a reliable high-throughput mRNA hybridization-based assay, providing a solution to better measure the 53-gene expression in FFPE tissues from patients. Its predictive power in GC was successfully validated in three hospital cohorts and patients with good prognostic scores exhibited a significantly better 5-year Overall Survival (OS) rate from adjuvant FOLFOX (leucovorin, fluorouracil, and oxaliplatin) chemotherapy after surgery than from other chemotherapies. Future work should focus on prospective trials to fully deploy this system into clinical utility.