ISSN: 2155-9554
Eric Bowman Jr, Laila Al-Eryani, Sikandar G. Khan, Kenneth Kraemer
A Xeroderma Pigmentosum (XP) is a genetically inherited recessive disorder. XP increases risk of skin cancer:
- nonmelanoma---10,000-fold,
- melanomas --- 2,000-fold
- tongue cancers --- 100,000-fold
• Estimated XP incidences in the USA are 1 in 1,000,0001 , 1 in 20,000 in Japan 5 , and approximately 2.3/ million live births in Western Europe 5
• XP has seven different complementation groups (A-G) translated for nucleotide excision DNA repair when exposed and damaged to UV light 1
• Mutation(s) in the XP genes result in a much slower rate of DNA repair
• Some XP patients become severely sunburned after minimal sun exposure with phenotypic expressions of lentigines and progressive neurological degeneration (XPA, XPD, XPG)
• XPC increases the likelihood of developing, earlyonset freckles and skin cancer 1