Zeitschrift für Forschung und Entwicklung
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Circulating Osteoprotegerin as Predictor of Global Systolic Dysfunction in Type Two Diabetes Patients with Chronic Heart Failure

Berezin AE, Kremzer AA, Samura TA

Background: Biomechanical stress and inflammatory biomarkers relate to global contractility dysfunction, however, adding these biomarkers into a risk model constructed on clinical data does not improve its prediction value in chronic heart failure (CHF).

Objectives: The aim of this study was to evaluate the interrelationship between left ventricular global contractility function and circulating biomarkers in diabetic patients with ischemia-induced CHF.

Patients and methods: The study retrospectively selected 54 T2DM subjects from 388 patients who had systolic or diastolic ischemia-induced CHF, that was defined as left-ventricular ejection fraction ≤ 45% or 46-55% respectively assessed by quantitative echocardiography and other conventional criteria according to current clinical guidelines. Two-dimensional transthoracic echocardiography and Tissue Doppler Imaging were performed according to a conventional method. Serum adiponectin, NT-proBNP, osteoprotegerin, and hs-CRP were determined at baseline by ELISA.

Results: We found lower global longitudinal strain and strain rate in T2DM patients with LVEF